P-91: Vitamin E and Selenium Supplementation Affects Aldehyde Oxidase, Xanthine Dehydrogenase/Oxidase Activities In Diabetic Rat Ovaries

Protective effects of vitamin E and selenium on spermatogenesis in adult male rat insulin-resistant

Background & Objective: Diabetes mellitus is a metabolic disease and is a multifactorial disorder characterized by chronic hyperglycemia resulting from impaired insulin secretion and insulin factional or both. In this study, the protective role of vitamin E and sodium selenite in preventing the harmful effects of insulin resistance (diabetes type 2) on spermatogenesis was studied.   Materials &...

Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk.

BACKGROUND The Selenium and Vitamin E Cancer Prevention Trial found no effect of selenium supplementation on prostate cancer (PCa) risk but a 17% increased risk from vitamin E supplementation. This case-cohort study investigates effects of selenium and vitamin E supplementation conditional upon baseline selenium status. METHODS There were 1739 total and 489 high-grade (Gleason 7-10) PCa cases...

P-27: The Effects of Combined Docosahexaenoic Acid and Vitamin E Supplementation onSpermatogram in Asthenozoospermic Men

Background: The motility patterns of spermatozoa correlate with the rate of natural pregnancy. It is not clear which compounds in spermatozoa or seminal plasma may be involved in the regulation of sperm motility. Considering the decrease of omega-3 fatty acids in spermatozoa of asthenozoospermic men, the aim of the present study was to investigate the effects of combined docosahexaenoic acid (D...

Role of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of Purine-Related Drugs

Purines are natural compounds that are found in all of the body's cells. They are the most widely distributed kind of N-heterocyclic substances in nature. Purines provide part of the chemical structure of some important co-enzymes and the genes of plants and animals. These compounds also participate in membrane signal transduction, translation and protein synthesis and in the form of purine nuc...

In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase.

In spite of over 40 years of clinical use of 6-mercaptopurine, many aspects of complex pharmacology and metabolism of this drug remain unclear. It is thought that 6-mercaptopurine is oxidized to 6-thiouric acid through 6-thioxanthine or 8-oxo-6-mercaptopurine by one of two molybdenum hydroxylases, xanthine oxidase (XO), however, the role of other molybdenum hydroxylase, aldehyde oxidase (AO), i...

Effects of selenium and vitamin e supplementation on concentrations of selenium and immunoglobulins in colostrum and blood of baluchi ewes and lambs and on lamb growth